An intravitreal injection is a procedure to place a medication directly into the space in the back of the eye called the vitreous cavity, which is filled with a jelly-like fluid called the vitreous humor gel. The procedure is usually performed by a trained retina specialist in the office setting.

What are intravitreal injections used for? 

Intravitreal injections are used to administer medications to treat a variety of retinal conditions. Age-related macular degeneration (AMD), diabetic retinopathy and retinal vein occlusion are the most common conditions treated with intravitreal anti-VEGF drugs. Intravitreal steroids are used in some eyes with diabetic retinopathy, retinal vein occlusion and uveitis. The anti-VEGF drugs and steroids help to reduce fluid leakage associated with these disorders. Antibiotic, anti fungal and antiviral drugs are also used to treat patients with infections in the eye such as endophthalmitis and retinitis. In some cases an injection is used to insert a small gas bubble to aid repair of a retinal detachment.

What kind of drugs can be given by intravitreal injection?

  • Anti-VEGF drugs
  • Steroids, which reduce inflammation
  • Antibiotics, antiviral and antifungal medications

The intravitreal injection procedure 

Intravitreal injections are performed in the operation theatre under strict sterile conditions First, the eye is anesthetized using drops so the injection doesn’t hurt. . 

The eye and the eyelids are then cleaned, usually using povidone-iodine, a yellow solution which is very effective at killing bacteria that live around the eye. Your face and the area around your eye will be covered by a drape to keep the area sterile  An eyelid speculum is used to keep the eyelids open during the procedure. Once the eye is prepped for injection, you will be asked to look in a particular direction depending on the location of the injection while the medicine is injected through the pars plana (the white part of the eye) with a very small needle 

Typically, patients may feel pressure, with little or no pain during the injection. After the injection, the speculum is removed and the eye is cleaned. The entire process takes about 5 to 10 minutes. You will be given antibiotic drops to take home with the instruction to put them in four times a day for five days.

Safety and results 

Severe complications are very rare with intravitreal injections. The major risks are:

  • Infection in the eye or endophthalmitis
  • Inflammation in the eye or pseudoendophthalmitis (a non-infectious inflammatory reaction to some medications)
  • Bleeding into the vitreous gel (vitreous hemorrhage)
  • Retinal detachment

Sometimes there may be a small bleed or subconjunctival hemorrhage on the surface of the eye where the needle enters; this usually heals within a week. Your retina specialist may check the intraocular pressure (IOP), that is, the pressure within the eye, following the injection. There may be a temporary rise in IOP that usually returns to baseline in a few minutes. The IOP may take longer to normalize in patients with glaucoma and needs to be monitored.

What to expect after the injection

There are usually no restrictions following the injection apart from avoiding potential contamination of the eye on the day of the injection. However, you  should contact your retina specialist if you experience signs and symptoms of complications, such as:

  •  Eye pain or discomfort
  • Increased floaters after the first day
  • Increased sensitivity to light
  • Decreased vision.

A follow-up visit with your retina specialist will be scheduled depending on the disease being treated, but is usually about 4 weeks after the injection.

Repeated intravitreal injections 

Intravitreal injections are an indispensable tool for the retina specialist to treat a variety of conditions. Intravitreal injections often need to be repeated in chronic conditions such as AMD, diabetic macular edema, and retinal vein occlusions, which require frequent clinic visits. Most patients require a loading course of three injections at regular intervals of four weeks. After the first three courses of injections, the majority of patients will require further injections depending on the disease. Repeat injections are usually safely tolerated over several years. The need for a repeat injections is determined during the clinical examination, often with the use of diagnostic testing such as OCT and FFA

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